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Principal tumors that secrete AFP are endodermal sinus tumor (yolk sac carcinoma), neuroblastoma, hepatoblastoma, and hepatocellular carcinoma.In patients with AFP-secreting tumors, serum levels of AFP often correlate with tumor size.Like any elevated tumor marker, elevated AFP by itself is not diagnostic, only suggestive.
Typically, MSAFP is measured in the beginning of the second trimester (14–16 weeks).
It may be measured alone or as part of a package of routine prenatal screening tests, such as a triple test or quad test.
MSAFP increases rapidly until about 32 weeks gestation, then decreases gradually.
After the pregnancy ends it decreases rapidly, with a half-life of about 5 days.
In the case of babies, after treatment AFP should go down faster than it would normally.
A temporary increase in AFP immediately following chemotherapy may indicate not that the tumor is growing but rather that it is shrinking (and releasing AFP as the tumor cells die).
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Superior reference ranges are produced by research on healthy subjects.Tags: Adult Dating, affair dating, sex dating